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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions contain:

It was only from the nineties nevertheless, when nanotechnology had Highly developed to some amount exactly where solitary molecules could be manipulated, that the primary experimental devices started to look.

, Groningen researchers present the outcomes of their attempts to produce labs far more sustainable and supply guidelines for other labs. 

Because 2000, Dekker has shifted the principle aim of his perform toward biophysics where he scientific studies the Houses of one biomolecules and cells using the resources of nanotechnology. This alteration of field was driven by his fascination to the amazing functioning of biological molecular structures, along with because of the extensive-time period perspective that a lot of exciting discoveries is often envisioned in this field.[5] Present lines of exploration in his biophysics team are from the parts of:[six]

That may be a dream of mine and we set to operate having a delightful dose of naivety. This is something which will most likely generate breathtaking ends in the longer phrase, but that doesn't make any difference. You should not only want to operate over the concerns of tomorrow, but in addition to the questions in the working day just after tomorrow.’

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two cees dekker electrodes

All parameters were being the same for each panel On this movie, apart from the First placement of your 6hb rod (revealed in blue) on the nanopore. Simulations that terminated early as a result of translocation on the rod from the pore are marked by a gray qualifications.

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

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It was all through this era that Dekker carried out study on magnetic spin techniques and on sound in superconductors and semiconductors.

In 1993 he was appointed as Affiliate Professor at Delft College of Technologies. While in the mid-nineteen nineties Dekker and his group reached achievements with the discovery in the Digital Attributes of carbon nanotubes, the very first solitary-molecule transistor together with other nanoscience.

Numerous new phenomena were being learned, and he and his analysis team set up a number one placement in this subject of study. Dekker and his exploration group discovered new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor based upon just one nanotube molecule.

2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA repair complexes; and 1st drive measurements on the DNA molecule in a very nanopore

‘I'm pushed by question and inquiries. On a fabric amount I find answers in physics, but I expertise my deepest pleasure with God. That religion also drives my science And just how I contend with people.